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Arachidonic acid (aa) is released from phospholipids in the cell membrane by cytosolic phospholipase a2 (cpla2) and catabolized into different metabolites mainly through cyclooxygenase (cox),. We herein present a synopsis of aa metabolism in human health, tissue homeostasis, and immunity, and explore the role of the aa metabolome in diverse pathophysiological conditions. Arachidonic acid metabolism refers to the biochemical processes that produce eicosanoids, which include prostaglandins and thromboxanes from the cox pathway, and leukotrienes from the.

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Arachidonic acid metabolites play a wide range of physiological roles in human health and diseases, aiding in cell proliferation and tissue regeneration and in the diagnosis of disease progression as well.

Understand how arachidonic acid is processed in the body, its role in generating key biological signals, and its profound influence on various aspects of health.

Thus, we herein present a synopsis of aa metabolism in human health, cardiovascular and cancer biology, and the signaling pathways involved in these processes. Aa metabolism is involved not only in cell differentiation, tissue development, and organ function but also in the progression of diseases, such as hepatic fibrosis, neurodegeneration, obesity, diabetes,. To explore the role of. Surrounding inflammation activates phospholipase a2, which cleaves and releases arachidonic acid (ara) from cell membranes.

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